TY - JOUR T1 - The metabolism of p-methoxyamphetamine in dog and monkey. O-demethylation as a major route. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 329 LP - 334 VL - 5 IS - 4 AU - J W Hubbard AU - K K Midha AU - J K Cooper Y1 - 1977/07/01 UR - http://dmd.aspetjournals.org/content/5/4/329.abstract N2 - p-Hydroxyamphetamine (PHA) and p-hydroxybenzoic acid (PHBA) have been isolated by gas-liquid chromatography (GC) as urinary metabolites of p-methoxyamphetamine (PMA) in dogs and rhesus monkeys. The amounts of PMA excreted unchanged in the total 24-hr urine samples in dogs and monkeys were 26% and 3%, respectively, of the total administered doses. The amounts of the pharmacologically active metabolite PHA excreted in 24-hr urine samples were 13% in the dog and 44% in the monkey. In the dog, 72% of the PHA was present as free (unconjugated) PHA, whereas in the monkey the amount of PHA present in the free form was only 14%. ER -