PT  - JOURNAL ARTICLE
AU  - F I Carroll
AU  - D Smith
AU  - L C Mark
AU  - L Brand
AU  - J M Perel
TI  - Determination of optically active thiopental, thiamylal, and their metabolites in human urine.
DP  - 1977 Jul 01
TA  - Drug Metabolism and Disposition
PG  - 343--354
VI  - 5
IP  - 4
4099  - http://dmd.aspetjournals.org/content/5/4/343.short
4100  - http://dmd.aspetjournals.org/content/5/4/343.full
SO  - Drug Metab Dispos1977 Jul 01; 5
AB  - Methods involving solvent extraction and gas-liquid chromatography have been developed for quantitative determination of certain thiobarbiturates and their major metabolites in urine. The structures of the metabolites identified were confirmed by the use of gas chromatography/mass spectrometry and 13C-nuclear magnetic resonance spectroscopy. The present analytic methods were applied to the quantitative determination of (R)-(+)- and (S)-(-)-thiopental as well as (R)-(+)- and (S)-(-)-thiamylal and their major metabolites excreted in human urine. Minor metabolites were isolated and identified.