TY - JOUR T1 - Determination of optically active thiopental, thiamylal, and their metabolites in human urine. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 343 LP - 354 VL - 5 IS - 4 AU - F I Carroll AU - D Smith AU - L C Mark AU - L Brand AU - J M Perel Y1 - 1977/07/01 UR - http://dmd.aspetjournals.org/content/5/4/343.abstract N2 - Methods involving solvent extraction and gas-liquid chromatography have been developed for quantitative determination of certain thiobarbiturates and their major metabolites in urine. The structures of the metabolites identified were confirmed by the use of gas chromatography/mass spectrometry and 13C-nuclear magnetic resonance spectroscopy. The present analytic methods were applied to the quantitative determination of (R)-(+)- and (S)-(-)-thiopental as well as (R)-(+)- and (S)-(-)-thiamylal and their major metabolites excreted in human urine. Minor metabolites were isolated and identified. ER -