RT Journal Article
SR Electronic
T1 The metabolism of styrene oxide in the isolated perfused rat liver. Identification and quantitation of major metabolites.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 363
OP 367
VO 5
IS 4
A1 A J Ryan
A1 J R Bend
YR 1977
UL http://dmd.aspetjournals.org/content/5/4/363.abstract
AB Isolated perfused rat livers rapidly metabolized 14C-styrene oxide. A large proportion of the administered radioactivity was excreted in the bile as a single compound that was identified as S-(1-phenyl-2-hydroxyethyl)glutathione by comparison with an authentic synthetic standard. The circulating perfusate was found to contain approximately equal amounts of styrene glycol, mandelic acid, and the glutathione derivative.