PT  - JOURNAL ARTICLE
AU  - I Chu
AU  - D C Villeneuve
AU  - V Secours
AU  - C Franklin
AU  - G Rock
AU  - A Viau
TI  - Metabolism and tissue distribution of mono-2-ethylhexyl phthalate in the rat.
DP  - 1978 Mar 01
TA  - Drug Metabolism and Disposition
PG  - 146--149
VI  - 6
IP  - 2
4099  - http://dmd.aspetjournals.org/content/6/2/146.short
4100  - http://dmd.aspetjournals.org/content/6/2/146.full
SO  - Drug Metab Dispos1978 Mar 01; 6
AB  - The absorption, distribution and metabolic excretion of mono-2-ethylhexyl [7-14C]phthalate (MEHP) were studied in the rat. This compound was readily absorbed from the gastrointestinal tract. Radioactivity following intravenous administration of 14C-MEHP was rapidly distributed in all tissues, with the highest levels occurring in the liver, kidney, and urinary bladder. Excretion of radioactivity was rapid and approximately 80% of the dose was eliminated 24 hr after oral administration, 72% in the urine and 8% in feces. MEHP was extensively metabolized after oral administration, and the major urinary metabolites were identified as an alcohol, a ketone, and an acid resulting from the side-chain oxidation of MEHP. A trace of o-phthalic acid was also identified.