RT Journal Article
SR Electronic
T1 Metabolism of levorotary 4,5-dihydrodiazepam in the rat.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 213
OP 217
VO 6
IS 3
A1 L Otvös
A1 Z Tegyey
A1 L Vereczkey
A1 M Ledniczky
A1 J Tamás
A1 E Pálosi
A1 L Szporny
YR 1978
UL http://dmd.aspetjournals.org/content/6/3/213.abstract
AB The metabolism of (-)-4,5-dihydrodiazepam (7-chloro-1,3,4,5-tetrahydro-1-methyl-5-phenyl-2H-1,4-benzo[2-14C]diazepin-2-one) (I) was investigated in rats. Metabolites from urine and bile extracts purified by thin-layer chromatography were identified by mass spectrometry. Diazepam and its main metabolites were found among the biotransformation products of I. Based on these findings, the most important identified metabolic route of the compound studied appears to be the formation of an unsaturated bond between the N4 and C5 atoms, and further transformation of the diazepam formed.