@article {Lynn494, author = {R K Lynn and R G Smith and R M Thompson and M L Deinzer and D Griffin and N Gerber}, title = {Characterization of glucuronide metabolites of carbamazepine in human urine by gas chromatography and mass spectrometry.}, volume = {6}, number = {4}, pages = {494--501}, year = {1978}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Glucuronide metabolites of carbamazepine (5 H-dibenz[b,f]azepine-5-carboxamide) were identified in human urine following chromatography on XAD-2 resin, permethylation, and combined gas chromatography and mass spectrometry with an SE-30 capillary column. Eight glucuronide metabolites, previously unidentified in man, were characterized as their permethylated derivatives. These included carbamazepine N-glucuronide (M+. 482), three isomers of dihydroxycarbamazepine O-glucuronide (M+. 542), three isomers of hydroxymethoxycarbamazepine O-glucuronide (M+. 542), and one isomer of hydroxycarbamazepine O-glucuronide (M+. 512). Other glucuronide metabolites, previously identified following enzymatic hydrolysis, were characterized as the unhydrolyzed, permethylated glucuronides, 10,11-dihydro-10,11-di--hydroxy carbamazepine O-glucuronide (M+. 544), and three isomers of monohydroxycarbamazepine O-glucuronide (M+. 512).}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/6/4/494}, eprint = {https://dmd.aspetjournals.org/content/6/4/494.full.pdf}, journal = {Drug Metabolism and Disposition} }