PT - JOURNAL ARTICLE AU - T Ishida AU - K Oguri AU - H Yoshimura TI - Isolation and identification of urinary metabolites of oxycodone in rabbits. DP - 1979 May 01 TA - Drug Metabolism and Disposition PG - 162--165 VI - 7 IP - 3 4099 - http://dmd.aspetjournals.org/content/7/3/162.short 4100 - http://dmd.aspetjournals.org/content/7/3/162.full SO - Drug Metab Dispos1979 May 01; 7 AB - Metabolism of oxycodone was studied in the rabbit and found to proceed through five metabolic pathways: O-demethylation, N-demethylation, N-oxidation, 6-keto reduction, and glucuronidation. Six urinary metabolites were isolated and identified in the unconjugated form: 14-hydroxydihydromorphinone, 14-hydroxydihydrocodeine, 14-hydroxydihydrocodeinone N-oxide (oxycodone N-oxide), 14-hydroxydihydroisocodeine, 14-hydroxydihydrocodeine N-oxide, and noroxycodone, together with unchanged oxycodone. Identification was made by means of various chromatographic and spectral comparisons with authentic samples. Oxycodone, 14-hydroxydihydromorphinone, 14-hydroxydihydrocodeine, 14-hydroxydihydroisocodeine, and noroxycodone were also identified as aglycons of conjugated metabolites.