PT - JOURNAL ARTICLE AU - M M Chien AU - J P Rosazza TI - Microbial transformations of natural antitumor agents. VIII. Formation of 8- and 9-hydroxyellipticines. DP - 1979 Jul 01 TA - Drug Metabolism and Disposition PG - 211--214 VI - 7 IP - 4 4099 - http://dmd.aspetjournals.org/content/7/4/211.short 4100 - http://dmd.aspetjournals.org/content/7/4/211.full SO - Drug Metab Dispos1979 Jul 01; 7 AB - Microbial transformations of ellipticine with Aspergillus alliaceus (NRRL 315) yielded two phenolic metabolites which were isolated and characterized as 8- and 9-hydroxyellipticines. The latter is a major metabolite and its structure was determined by NMR and mass-spectometric analyses, and by comparison with authentic 9-hydroxyellipticine prepared by chemical demethylation of 9-methoxyellipticine. The structure of 8-hydroxyellipticine was determined primarily by NMR spectrometry. Whereas 8-hydroxyellipticine is a new derivative, 9-hydroxyellipticine has been described, and it is one of the major mammalian metabolites of the antitumor alkaloid ellipticine.