PT  - JOURNAL ARTICLE
AU  - Acara, M
AU  - Gessner, T
AU  - Greizerstein, H
AU  - Trudnowski, R
TI  - Renal N-oxidation of meperidine by the perfused kidney of the rat.
DP  - 1981 Mar 01
TA  - Drug Metabolism and Disposition
PG  - 75--79
VI  - 9
IP  - 2
4099  - http://dmd.aspetjournals.org/content/9/2/75.short
4100  - http://dmd.aspetjournals.org/content/9/2/75.full
SO  - Drug Metab Dispos1981 Mar 01; 9
AB  - Isolated perfused kidneys of rats were used to determined renal metabolism of meperidine and its relation to meperidine excretion. Starting perfusate concentrations of meperidine were 18.4 and 190 micrograms/ml, and resulted in respective nonsaturation and saturation kinetics for removal of meperidine. Disposition of 14C-meperidine was followed and supplemented with measurements of meperidine by gas chromatography. A major renal metabolite was shown to facilitate the renal excretion of meperidine. This metabolite was identified by gas chromatography/mass spectrometry as the N-oxide of meperidine.