RT Journal Article
SR Electronic
T1 The biodistribution and metabolic fate of inhaled 11C-octanal in the rat after acute exposure.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 331
OP 333
VO 9
IS 4
A1 R S Kutzman
A1 G J Meyer
A1 A P Wolf
A1 T Akasaka
YR 1981
UL http://dmd.aspetjournals.org/content/9/4/331.abstract
AB Rats were nose exposed to an atmosphere containing 11.4 ppm of 11C-octanal for 2 min. Inhaled octanal was absorbed from the lungs in a biphasic manner and the greatest concentration of octanal occurred in most tissues at 5 min. Tissue activities calculated on the basis of the administered dose and on the radiolabel retained until the animal was killed indicated a redistribution of the radiolabel as metabolic products after 20 min. The labeled carbon was eliminated in a biphasic manner as 11CO2, which accounted for essentially all of the activity lost by the exposed rats.