RT Journal Article
SR Electronic
T1 Metabolites of feprazone in man.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 340
OP 344
VO 7
IS 5
A1 Yamaguchi, H
A1 Kubo, J
A1 Sekine, K
A1 Naruchi, T
A1 Hashimoto, Y
A1 Kato, R
YR 1979
UL http://dmd.aspetjournals.org/content/7/5/340.abstract
AB Two male volunteers received 400 mg of nonlabeled feprazone, 1,2-diphenyl-3,5-dioxo-4-(3'-methyl-but-2'-enyl)pyrazolidine. Metabolites were extracted and isolated by chromatography on silica gel. Isolated metabolites were unchanged drug, E-1,2-diphenyl-3,5-dioxo-4-(3'-hydroxymethyl-but-2'-enyl)pyrazolidine, and feprazone (C4)-beta-glucuronide. Feprazone (C4)-beta-glucuronide was the main metabolite and it belongs to a novel type of conjugate, (C)-beta-glucuronide.