PT  - JOURNAL ARTICLE
AU  - R J Bopp
AU  - J F Nash
AU  - A S Ridolfo
AU  - E R Shepard
TI  - Stereoselective inversion of (R)-(-)-benoxaprofen to the (S)-(+)-enantiomer in humans.
DP  - 1979 Nov 01
TA  - Drug Metabolism and Disposition
PG  - 356--359
VI  - 7
IP  - 6
4099  - http://dmd.aspetjournals.org/content/7/6/356.short
4100  - http://dmd.aspetjournals.org/content/7/6/356.full
SO  - Drug Metab Dispos1979 Nov 01; 7
AB  - The enantiomeric composition of benoxaprofen [(RS)-2-(P-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid] in plasma and urine was determined after oral administration of both the racemic mixture and the (R)-(-)-enantiomer to normal human volunteers. Resolution of the diastereomeric amides, formed by the reaction of the enantiomers with (S)-(-)-apha-methylbenzylamine, was accomplished by gas chromatography. The (R)-(-1)-enantiomer of the parent drug was stereoselectively inverted to its (S)-(+) isomer in humans.