RT Journal Article
SR Electronic
T1 Metabolism of acebutolol-d6 in the rat correlates with the identification of a new metabolite in human urine.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 360
OP 365
VO 7
IS 6
A1 B D Andresen
A1 F T Davis
YR 1979
UL http://dmd.aspetjournals.org/content/7/6/360.abstract
AB The metabolism and excretion of acebutolol-d6, [1-(2-acetyl-4-n-butyramido-phenoxy)-2-hydroxy-3--[2H6]isopropylaminopropane] has been studied in the rat. Metabolites were characterized by thin-layer and gas chromatography, mass spectrometry, and the direct comparisons of metabolites to synthetic standards. Approximately 60% of the parent drug was excreted unchanged. Two major metabolites, an acetamide and an aniline, were identified in urine samples at relative concentrations of approximately 10% and 30%, respectively. The aniline analog of acebutolol was also identified in human urine.