PT  - JOURNAL ARTICLE
AU  - B N Swanson
AU  - D W Zaharevitz
AU  - M B Sporn
TI  - Pharmacokinetics of N-(4-hydroxyphenyl)-all-trans-retinamide in rats.
AID  - 10.1124/dmd.8.3.168
DP  - 1980 May 01
TA  - Drug Metabolism and Disposition
PG  - 168--172
VI  - 8
IP  - 3
4099  - http://dmd.aspetjournals.org/content/8/3/168.short
4100  - http://dmd.aspetjournals.org/content/8/3/168.full
SO  - Drug Metab Dispos1980 May 01; 8
AB  - The concentration of N-(4-hydroxyphenyl)-all-trans-retinamide (HPR) was determined in plasma and a variety of tissues from rats after an intravenous dose (5 mg/kg). The plasma concentration-time curve could be accurately described by a triexponential equation. The apparent volume of distribution of HPR was approximately 10-12 liter/kg and the terminal half-life was 12 hr. Metabolites of HPR were more abundant than intact drug in most tissues 24 hr after the iv dose. A 5-day excretion study with radiolabeled HPR revealed that less than 2% of a single iv dose (5 mg/kg) is excreted as unmetabolized HPR in urine and feces and that most of the radioactivity is eliminated in the feces. HPR was incompletely absorbed after an oral dose (10 mg/kg).