RT Journal Article
SR Electronic
T1 Antipyrine pharmacokinetics in the pregnant rat.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 265
OP 267
VO 8
IS 4
A1 M Dean
A1 L O'Donnell
A1 S Penglis
A1 B Stock
YR 1980
UL http://dmd.aspetjournals.org/content/8/4/265.abstract
AB Pronounced differences in pharmacokinetic parameters of antipyrine have been found in the 20-day pregnant hooded Wistar rat when compared with nonpregnant controls. Total body clearance falls significantly from 5.93 to 3.5 ml/min/kg in the pregnant rat whereas no significant increase in antipyrine volume of distribution occurs. These changes result in an increase in antipyrine half-life from 109 to 223 min in the pregnant rat. This study demonstrates that reduced hepatic mono-oxygenase capacity exists in the pregnant rat and that this can markedly affect drug clearance in there animals.