TY - JOUR T1 - Biodisposition of theophylline. II. Effect of aromatic hydrocarbon treatment in mice. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 271 LP - 273 VL - 8 IS - 4 AU - C J Betlach AU - T N Tozer Y1 - 1980/07/01 UR - http://dmd.aspetjournals.org/content/8/4/271.abstract N2 - The effect of polycyclic aromatic hydrocarbons on theophylline clearance was examined in six inbred mice strains. The DBA/2 and SJL strains were nonresponsive to this treatment, whereas C3H/HeJ, C57BL/6, BALB/c, and A/J strains were responsive. In the responsive strains, the total body clearance increased by a factor of 2.3 to 3.4, apparently due to a general induction of all metabolic pathways. The production of 1,3-dimethyluric acid was not increased in the C57BL/6 strain. The variation in induction among responsive strains appeared to be primarily associated with the increase in the oxidation to 1,3-dimethyluric acid. ER -