RT Journal Article
SR Electronic
T1 Biodisposition of theophylline. II. Effect of aromatic hydrocarbon treatment in mice.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 271
OP 273
VO 8
IS 4
A1 C J Betlach
A1 T N Tozer
YR 1980
UL http://dmd.aspetjournals.org/content/8/4/271.abstract
AB The effect of polycyclic aromatic hydrocarbons on theophylline clearance was examined in six inbred mice strains. The DBA/2 and SJL strains were nonresponsive to this treatment, whereas C3H/HeJ, C57BL/6, BALB/c, and A/J strains were responsive. In the responsive strains, the total body clearance increased by a factor of 2.3 to 3.4, apparently due to a general induction of all metabolic pathways. The production of 1,3-dimethyluric acid was not increased in the C57BL/6 strain. The variation in induction among responsive strains appeared to be primarily associated with the increase in the oxidation to 1,3-dimethyluric acid.