TY - JOUR T1 - Prediction of Human Pharmacokinetics in 2013 and Beyond JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 1973 LP - 1974 DO - 10.1124/dmd.113.055376 VL - 41 IS - 12 AU - J. Brian Houston Y1 - 2013/12/01 UR - http://dmd.aspetjournals.org/content/41/12/1973.abstract N2 - The utility of in vitro generated kinetic data to provide quantitative prediction of in vivo pharmacokinetic behavior is well established and forms a cornerstone of many research projects in drug metabolism and disposition, particularly within the pharmaceutical industry. This issue provides several excellent examples of the use of in vitro techniques for prediction of human pharmacokinetics (PK). The general area of in vitro–in vivo extrapolation (IVIVE) is broad and hence the spectrum of topics covers various aspects drug clearance and distribution and drug-drug interactions. Some articles were commissioned whereas others were identified during the reviewing process. Overall they provide a snapshot of activity at the end of 2013. They document that whereas the translation of some in vitro approaches is now established, other areas are in their infancy and need more development. ER -