PT  - JOURNAL ARTICLE
AU  - J. Brian Houston
TI  - Prediction of Human Pharmacokinetics in 2013 and Beyond
AID  - 10.1124/dmd.113.055376
DP  - 2013 Dec 01
TA  - Drug Metabolism and Disposition
PG  - 1973--1974
VI  - 41
IP  - 12
4099  - http://dmd.aspetjournals.org/content/41/12/1973.short
4100  - http://dmd.aspetjournals.org/content/41/12/1973.full
SO  - Drug Metab Dispos2013 Dec 01; 41
AB  - The utility of in vitro generated kinetic data to provide quantitative prediction of in vivo pharmacokinetic behavior is well established and forms a cornerstone of many research projects in drug metabolism and disposition, particularly within the pharmaceutical industry. This issue provides several excellent examples of the use of in vitro techniques for prediction of human pharmacokinetics (PK). The general area of in vitro–in vivo extrapolation (IVIVE) is broad and hence the spectrum of topics covers various aspects drug clearance and distribution and drug-drug interactions. Some articles were commissioned whereas others were identified during the reviewing process. Overall they provide a snapshot of activity at the end of 2013. They document that whereas the translation of some in vitro approaches is now established, other areas are in their infancy and need more development.