RT Journal Article
SR Electronic
T1 Potential Role of Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 1725
OP 1731
DO 10.1124/dmd.113.053157
VO 41
IS 10
A1 Magnus Ingelman-Sundberg
A1 Xiao-Bo Zhong
A1 Oliver Hankinson
A1 Sudheer Beedanagari
A1 Ai-Ming Yu
A1 Lai Peng
A1 Yoichi Osawa
YR 2013
UL http://dmd.aspetjournals.org/content/41/10/1725.abstract
AB This is a report of a symposium on the potential role of epigenetic mechanisms in the control of drug disposition sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 2013 meeting in Boston, MA, April 21, 2013. Epigenetics is a rapidly evolving area, and recent studies have revealed that expression of drug-metabolizing enzymes and transporters is regulated by epigenetic factors, including histone modification, DNA methylation, and noncoding RNAs. The symposium speakers provided an overview of genetic and epigenetic mechanisms underlying variable drug metabolism and drug response, as well as the implications for personalized medicine. Considerable insight into the epigenetic mechanisms in differential regulation of the dioxin-inducible drug and carcinogen-metabolizing enzymes CYP1A1 and 1B1 was provided. The role of noncoding microRNAs in the control of drug metabolism and disposition through targeting of cytochrome P450 (P450) enzymes and ATP-binding cassette membrane transporters was discussed. In addition, potential effects of xenobiotics on chromatin interactions and epigenomics, as well as the possible role of long noncoding RNAs in regulation of P450s during liver maturation were presented.