RT Journal Article SR Electronic T1 The complicated role of Nrf2 in allergy and asthma JF Drug Metabolism and Disposition JO Drug Metab Dispos FD American Society for Pharmacology and Experimental Therapeutics SP DMD-MR-2021-000414 DO 10.1124/dmd.121.000414 A1 Cheryl E. Rockwell A1 Yining Jin A1 Allison P Boss A1 Luca M Kaiser A1 Saamera Awali YR 2021 UL http://dmd.aspetjournals.org/content/early/2021/12/20/dmd.121.000414.abstract AB Nrf2 is a stress-activated transcription factor that is highly responsive to oxidative stress and electrophilic stimuli. Upon activation, Nrf2 upregulates a battery of cytoprotective genes meant to prevent cell death and/or damage. In many models of inflammation, Nrf2 protects against the immune response and decreases injury, including in the context of asthma and allergy. However, in some models of asthma and allergy, Nrf2 either does not play a role or can even exacerbate inflammation. In general, the reasons behind these discrepencies are not clear and the mechanisms by which Nrf2 modulates immune response are largely uncharacterized. The aim of this review is to highlight current literature assessing the role of Nrf2 in allergy and asthma to understand Nrf2 as a potential therapeutic target. Significance Statement Nrf2 is an important immune mediator that modulates numerous immune cell types in various inflammatory diseases, including allergy and asthma. There is considerable interest in Nrf2 as a drug target in inflammation, which is complicated by the complex nature of Nrf2 in the immune system. This review focuses on the role of Nrf2 in asthma and allergy, including the endogenous role of Nrf2 in regulating immune cell function and the role of Nrf2 in detoxifying xenobiotics that exacerbate these diseases.