TY - JOUR T1 - The in vivo pharmacokinetics of block copolymers containing polyethylene glycol used in nanocarrier drug delivery systems JF - Drug Metabolism and Disposition JO - Drug Metab Dispos DO - 10.1124/dmd.121.000568 SP - DMD-MR-2021-000568 AU - Lei Yin AU - Yiling Pang AU - Lin Shan AU - Jingkai Gu Y1 - 2022/01/01 UR - http://dmd.aspetjournals.org/content/early/2022/01/21/dmd.121.000568.abstract N2 - Polyethylene glycol is one of the most commonly used synthetic macromolecular polymers for modifying small molecule drugs, peptides, proteins or Nano-drug delivery systems to improve their water solubility, biocompatibility and stability. Block copolymers containing PEG have been widely used in Nano-drug delivery systems such as solid lipid nanoparticles, polymeric nanoparticles, polymeric micelles and liposomes. To date, although numerous PEGylated Nano-drug delivery systems have been developed, only a few have been approved for clinical application. Poor safety and effectivity are important reasons for the high failure of Nano-drug delivery systems clinical trials. These factors are not only related to the loaded drugs and released drugs, but also related to the nanocarriers. Therefore, investigating the in vivo spatiotemporal fate of block copolymers containing PEG used in Nano-drug delivery systems is necessary and important for evaluating their safety, efficacy and toxicity. In this article, we will review the information that has been reported about the absorption, distribution, metabolism and excretion of block copolymers containing PEG. We believe this review is helpful to understand the biological fate of block copolymers containing PEG. Significance Statement This review describes pharmacokinetic study of block copolymers containing polyethylene. The main focus of this paper is the in vivo fate of these PEG related copolymers after their release from Nanocarriers. This review is helpful for understanding of the in vivo fate of block copolymers containing polyethylene glycol used in Nanocarrier drug delivery system. ER -