PT  - JOURNAL ARTICLE
AU  - Zhao, Pengfei
AU  - Fan, Shicheng
AU  - Gao, Yue
AU  - Huang, Min
AU  - Bi, Huichang
TI  - Nuclear Receptor-Mediated Hepatomegaly and Liver Regeneration: An Update
AID  - 10.1124/dmd.121.000454
DP  - 2022 May 01
TA  - Drug Metabolism and Disposition
PG  - 636--645
VI  - 50
IP  - 5
4099  - http://dmd.aspetjournals.org/content/50/5/636.short
4100  - http://dmd.aspetjournals.org/content/50/5/636.full
SO  - Drug Metab Dispos2022 May 01; 50
AB  - Nuclear receptors (NRs), a superfamily of ligand-activated transcription factors, are critical in cell growth, proliferation, differentiation, metabolism, and numerous biologic events. NRs have been reported to play important roles in hepatomegaly (liver enlargement) and liver regeneration by regulating target genes or interacting with other signals. In this review, the roles and involved molecular mechanisms of NRs in hepatomegaly and liver regeneration are summarized and the future perspectives of NRs in the treatment of liver diseases are discussed.SIGNIFICANCE STATEMENT NRs play critical roles in hepatomegaly and liver regeneration, indicating the potential of NRs as targets to promote liver repair after liver injury. This paper reviews the characteristics and molecular mechanisms of NRs in regulating hepatomegaly and liver regeneration, providing more evidence for NRs in the treatment of related liver diseases.