RT Journal Article
SR Electronic
T1 Nuclear Receptor-Mediated Hepatomegaly and Liver Regeneration: An Update
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 636
OP 645
DO 10.1124/dmd.121.000454
VO 50
IS 5
A1 Zhao, Pengfei
A1 Fan, Shicheng
A1 Gao, Yue
A1 Huang, Min
A1 Bi, Huichang
YR 2022
UL http://dmd.aspetjournals.org/content/50/5/636.abstract
AB Nuclear receptors (NRs), a superfamily of ligand-activated transcription factors, are critical in cell growth, proliferation, differentiation, metabolism, and numerous biologic events. NRs have been reported to play important roles in hepatomegaly (liver enlargement) and liver regeneration by regulating target genes or interacting with other signals. In this review, the roles and involved molecular mechanisms of NRs in hepatomegaly and liver regeneration are summarized and the future perspectives of NRs in the treatment of liver diseases are discussed.SIGNIFICANCE STATEMENT NRs play critical roles in hepatomegaly and liver regeneration, indicating the potential of NRs as targets to promote liver repair after liver injury. This paper reviews the characteristics and molecular mechanisms of NRs in regulating hepatomegaly and liver regeneration, providing more evidence for NRs in the treatment of related liver diseases.