RT Journal Article
SR Electronic
T1 Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 685
OP 693
DO 10.1124/dmd.121.000455
VO 50
IS 5
A1 Yangliu Xia
A1 Mingrui Yan
A1 Ping Wang
A1 Keisuke Hamada
A1 Nana Yan
A1 Haiping Hao
A1 Frank J. Gonzalez
A1 Tingting Yan
YR 2022
UL http://dmd.aspetjournals.org/content/50/5/685.abstract
AB Withaferin A (WA) is a natural steroidal compound used in Ayurvedic medicine in India and elsewhere. Although WA was used as an anticancer reagent for decades, its role in the treatment of liver diseases has only recently been experimentally explored. Here, the effects of WA in the treatment of liver injury, systematic inflammation, and liver cancer are reviewed, and the toxicity and metabolism of WA as well as pharmacological potentials of other extracts from Withania somnifera (W. somnifera) discussed. The pharmacokinetic behaviors of WA are summarized and pharmacokinetic insights into current progress and future opportunities are highlighted.SIGNIFICANCE STATEMENT This review outlines the current experimental progress of Withaferin A (WA) hepatoprotective activities and highlights gaps in the field. This work also discusses the pharmacokinetics of WA that can be used to guide future studies for the possible treatment of liver diseases with this compound.