TY - JOUR T1 - Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 685 LP - 693 DO - 10.1124/dmd.121.000455 VL - 50 IS - 5 AU - Yangliu Xia AU - Mingrui Yan AU - Ping Wang AU - Keisuke Hamada AU - Nana Yan AU - Haiping Hao AU - Frank J. Gonzalez AU - Tingting Yan Y1 - 2022/05/01 UR - http://dmd.aspetjournals.org/content/50/5/685.abstract N2 - Withaferin A (WA) is a natural steroidal compound used in Ayurvedic medicine in India and elsewhere. Although WA was used as an anticancer reagent for decades, its role in the treatment of liver diseases has only recently been experimentally explored. Here, the effects of WA in the treatment of liver injury, systematic inflammation, and liver cancer are reviewed, and the toxicity and metabolism of WA as well as pharmacological potentials of other extracts from Withania somnifera (W. somnifera) discussed. The pharmacokinetic behaviors of WA are summarized and pharmacokinetic insights into current progress and future opportunities are highlighted.SIGNIFICANCE STATEMENT This review outlines the current experimental progress of Withaferin A (WA) hepatoprotective activities and highlights gaps in the field. This work also discusses the pharmacokinetics of WA that can be used to guide future studies for the possible treatment of liver diseases with this compound. ER -