TABLE 3

Statistical analysis of fraction unbound for various species

X	Y	Intercept	S.E.	P	Slope	S.E.	P	Correlation Coefficient
Wistar Han 1	Wistar Han 2	0.014	0.042	0.741	0.999	0.025	0.978	0.986
Wistar Han 1	SD rat	−0.090	0.069	0.201	1.002	0.041	0.970	0.964
Wistar Han 1	CD-1 mouse	0.056	0.057	0.334	1.028	0.034	0.417	0.976
Wistar Han 1	Hartley guinea pig	0.021	0.048	0.656	1.053	0.028	0.064	0.984
Wistar Han 1	Beagle dog	0.165	0.102	0.113	1.046	0.061	0.454	0.930
Wistar Han 1	Cynomolgus monkey	0.008	0.055	0.881	0.969	0.033	0.347	0.975
Wistar Han 1	Human	0.010	0.045	0.821	1.002	0.027	0.955	0.984
Wistar Han 2	Wistar Han 1	−0.014	0.042	0.740	1.001	0.025	0.978	0.986
Wistar Han 2	SD rat	−0.104	0.057	0.084	1.002	0.035	0.950	0.973
Wistar Han 2	CD-1 mouse	0.042	0.055	0.456	1.028	0.033	0.393	0.977
Wistar Han 2	Hartley guinea pig	0.006	0.039	0.873	1.054	0.023	0.026	0.989
Wistar Han 2	Beagle dog	0.150	0.087	0.094	1.046	0.052	0.386	0.947
Wistar Han 2	Cynomolgus monkey	−0.005	0.046	0.919	0.970	0.028	0.277	0.982
Wistar Han 2	Human	−0.004	0.033	0.913	1.002	0.018	0.913	0.991
SD rat	Wistar Han 1	0.090	0.072	0.221	0.999	0.041	0.970	0.964
SD rat	Wistar Han 2	0.103	0.062	0.101	0.998	0.035	0.950	0.973
SD rat	CD-1 mouse	0.149	0.084	0.083	1.027	0.047	0.575	0.954
SD rat	Hartley guinea pig	0.117	0.063	0.072	1.052	0.036	0.150	0.975
SD rat	Beagle dog	0.256	0.077	0.002	1.043	0.043	0.328	0.963
SD rat	Cynomolgus monkey	0.095	0.068	0.171	0.967	0.038	0.396	0.966
SD rat	Human	0.100	0.058	0.091	1.000	0.033	1.000	0.976
CD-1 mouse	Wistar Han 1	−0.054	0.054	0.321	0.973	0.032	0.405	0.976
CD-1 mouse	Wistar Han 2	−0.040	0.053	0.446	0.972	0.031	0.380	0.977
CD-1 mouse	SD rat	−0.145	0.076	0.062	0.974	0.045	0.565	0.954
CD-1 mouse	Hartley guinea pig	−0.035	0.055	0.523	1.025	0.033	0.440	0.978
CD-1 mouse	Beagle dog	0.106	0.087	0.228	1.016	0.052	0.756	0.946
CD-1 mouse	Cynomolgus monkey	−0.044	0.054	0.411	0.943	0.032	0.077	0.975
CD-1 mouse	Human	−0.044	0.053	0.410	0.975	0.031	0.422	0.977
Hartley guinea pig	Wistar Han 1	−0.020	0.045	0.653	0.949	0.025	0.052	0.984
Hartley guinea pig	Wistar Han 2	−0.006	0.037	0.872	0.949	0.021	0.020	0.989
Hartley guinea pig	SD rat	−0.111	0.057	0.057	0.950	0.032	0.130	0.975
Hartley guinea pig	CD-1 mouse	0.035	0.055	0.530	0.975	0.031	0.429	0.978
Hartley guinea pig	Beagle dog	0.140	0.075	0.068	0.990	0.043	0.822	0.960
Hartley guinea pig	Cynomolgus monkey	−0.010	0.0343	0.769	0.921	0.019	0.0002	0.990
Hartley guinea pig	Human	−0.009	0.0267	0.730	0.951	0.015	0.002	0.994
Beagle dog	Wistar Han 1	−0.158	0.090	0.085	0.956	0.056	0.434	0.930
Beagle dog	Wistar Han 2	−0.143	0.077	0.071	0.956	0.048	0.364	0.947
Beagle dog	SD rat	−0.246	0.065	0.0004	0.959	0.040	0.308	0.963
Beagle dog	CD-1 mouse	−0.104	0.081	0.203	0.984	0.050	0.752	0.946
Beagle dog	Hartley guinea pig	−0.141	0.070	0.050	1.010	0.043	0.823	0.960
Cynomolgus monkey	Wistar Han 1	−0.009	0.057	0.880	1.032	0.035	0.362	0.975
Cynomolgus monkey	Wistar Han 2	0.005	0.048	0.919	1.031	0.029	0.291	0.982
Cynomolgus monkey	SD rat	−0.098	0.067	0.150	1.034	0.041	0.412	0.966
Cynomolgus monkey	CD-1 mouse	0.047	0.058	0.423	1.061	0.036	0.095	0.975
Cynomolgus monkey	Hartley guinea pig	0.011	0.037	0.770	1.086	0.023	0.001	0.990
Cynomolgus monkey	Beagle dog	0.155	0.073	0.041	1.078	0.045	0.089	0.962
Cynomolgus monkey	Human	0.001	0.033	0.981	1.033	0.020	0.108	0.991
Human	Wistar Han 1	−0.010	0.045	0.820	0.999	0.027	0.955	0.984
Human	Wistar Han 2	0.004	0.033	0.914	0.998	0.020	0.913	0.991
Human	SD rat	−0.100	0.055	0.076	1.000	0.033	1.000	0.976
Human	CD-1 mouse	0.045	0.056	0.421	1.026	0.033	0.434	0.977
Human	Hartley guinea pig	0.010	0.028	0.731	1.051	0.017	0.004	0.994
Human	Beagle dog	0.152	0.073	0.044	1.043	0.044	0.331	0.962
Human	Cynomolgus monkey	−0.001	0.032	0.981	0.968	0.019	0.097	0.991