TABLE 6

Dose regimens of three inducers in drug interaction studies from literature

Data were extracted from the Metabolism and Transporter Drug Interaction Database (searched in July 2010).

InducerDosing RegimenNo. Studies% Studies
Rifampin600 mg once daily (600 mg q.d.)25476
450 mg once daily (450 mg q.d.)257
300 mg twice daily (300 mg b.i.d.)185
Other3912
Total336
Carbamazepine200 mg once daily (200 mg q.d.)812
200 mg twice daily (200 mg b.i.d.)1218
600 mg once daily (600 mg q.d.)57
300 mg twice daily (300 mg b.i.d.)23
Other4160
Total68
Phenobarbital60 mg once daily (60 mg q.d.)12
60 mg twice daily (60 mg b.i.d.)36
100 mg once daily (100 mg q.d.)2446
200 mg once daily (200 mg q.d.)12
Other2644
Total52