TABLE 5

Predicted and observed pharmacokinetic parameters of CYP3A4 substrates after a single oral dose

SubstrateDoseCmaxAUCReference
PredictedObservedPredictedObserved
mgng/mlng · h/ml
Midazolam828.128.3 ± 14.1175167 ± 104Uchida et al., 2006
Nifedipine1075.264.8 ± 34.1341216 ± 93.2Lang et al., 2003
Simvastatin405.546.87 ± 3.3043.425.2 ± 16.6Backman et al., 2000
Zolpidem10107112 ± 50751528 ± 337Saari et al., 2007