TABLE 4

Predicted and observed pharmacokinetic parameters of CYP3A4 inducers after multiple oral doses

Inducer	Dose Regimen	C_{max, ss}		AUC_ss		Reference
Inducer	Dose Regimen	Predicted	Observed	Predicted	Observed	Reference
		μg/ml		μg · h/ml
Rifampin	300 mg b.i.d. for 14 days	4.04	4.5 ± 1.44	33.2	13.5 ± 4.2	Drusano et al., 1986
Carbamazepine	200 mg b.i.d. for 32 days	6.78–12.2^{^a}	6.97 ± 0.64	98.7–182^{^a}	70.3 ± 8.92	Rapeport et al., 1996
Phenobarbital	100 mg q.d. for 38 days	13.4	16.8	354	342	Reidenberg et al., 1995

↵a The predicted C_{max, ss} and AUC_ss values for CBZ are the range of Simcyp predictions using the in vitro CYP3A4 induction data from the respective three hepatocyte donors (donor 1, 2, or 3 in Table 2).