TABLE 3

fm, CYP3A4 of various CYP3A4 substrates (n = 100 individuals) used in Simcyp for simulation

fm, CYP3A4
Mean (S.D.)Median (5th–95th percentile)
%
Nifedipine98.1 (4.1)100 (88.6–100)
Simvastatin83.1 (12.0)87.1 (56.4–96.6)
Midazolam83.7 (29.8)100 (20.0–100)
Zolpidem40.8 (17.8)39.3 (15.3–72.8)