Estimated IC50 values (μM) for CYP3A4 inhibitors (bromocriptine and ketoconazole) and CYP2D6 inhibitors (ropinirole, pergolide and quinidine)
| CYP Enzyme | Inhibitor | Determined IC50 |
|---|---|---|
| 3A4 | Bromocriptine | 1.69 μM |
| 3A4 | Ketoconazole | 0.01 μM |
| 2D6 | Ropinirole | 0.54 μM |
| 2D6 | Pergolide | 0.08 μM |
| 2D6 | Quinidine | 0.12 μM |
Values represent the mean of triplicate determinations of remaining P450 activity compared to control in cDNA-expressed CYP microsomal incubations.