Table 1

Effect of caffeine and 7,8-benzoflavone on APAP-3-GSH formation in adult rat liver microsomes

	7,8-Benzoflavone
	0	50 μM
	(nmol APAP-3-GSH formed/min/mg prot)
Caffeine (mM)
0	0.32 ± 0.02^1-a	1.32 ± 0.02
10	1.65 ± 0.03^1-b	0.96 ± 0.03^1-c

The concentration of acetaminophen was 1.0 mM. Values are mean ± SD, N = 3.
↵1-a Control vs. 50 μM 7,8-benzoflavone,p < 0.05.
↵1-b Control vs. 10 mM caffeine, p< 0.05.
↵1-c 10 mM caffeine vs combination of 10 mM caffeine and 7,8-benzoflavone.
p < 0.05.