Control microsomes | 1 | 17.2 ± 0.1 | 100 | 100 |
25 μM 5-FU | 1 | 16.8 ± 0.1 | 97.8 | 97.6 |
25 μM NaF | 1 | 15.8 ± 0.2 | 91.9 | 91.02-c |
100 μM NaF | 1 | 15.1 ± 0.1 | 87.6 | 86.32-d
|
500 μM NaF | 1 | 11.8 ± 0.1 | 68.7 | 65.42-d |
25 μM BNPP | 1 | 1.9 ± 0.1 | 10.8 | 1.32-d
|
100 μM BNPP | 1 | 1.9 ± 0.1 | 11.1 | 1.62-d |
25 μM probenecid | 1 | 15.1 ± 0.1 | 88.1 | 86.82-c |
Phosphate control | 1 | 1.6 ± 0.1 | 9.3 | −0.52-d
|
Boiled microsomes | 1 | 1.7 ± 0.2 | 9.7 | 0.02-d |
Control microsomes | 2 | 15.1 ± 0.5 | 100 | 100 |
44 μM HMB2-a
| 2 | 14.8 ± 0.3 | 101 | 101 |
21 μM CMB2-a
| 2 | 15.4 ± 0.6 | 105 | 106 |
24 μM loperamide2-a
| 2 | 13.6 ± 0.5 | 93.2 | 92.5 |
Control with MeOH | 2 | 14.6 ± 0.2 | 96.8 | 96.5 |
25 μM EtOH | 2 | 14.4 ± 0.1 | 95.6 | 95.1 |
100 μM EtOH | 2 | 14.2 ± 0.3 | 94.1 | 93.5 |
26 μM BNPP | 2 | 1.6 ± 0.1 | 10.4 | 1.52-b |
Phosphate control | 2 | 1.4 ± 0.0 | 9.4 | 0.32-d
|
Boiled microsomes | 2 | 1.4 ± 0.1 | 9.1 | 0.02-c |
Control microsomes | 3 | 11.3 ± 0.2 | 100 | 100 |
36 μM caffeine2-a
| 3 | 11.0 ± 0.1 | 97.7 | 97.5 |
32 μM metoclopramide2-a
| 3 | 10.3 ± 0.1 | 91.6 | 90.92-c |
28 μM acetaminophen2-a
| 3 | 10.5 ± 0.2 | 93.6 | 93.02-b |
Control with MeOH | 3 | 10.6 ± 0.1 | 94.0 | 93.4 |
26 μM Coumarin2-a
| 3 | 10.5 ± 0.2 | 99.2 | 99.2 |
39 μM ASA2-a
| 3 | 10.5 ± 0.4 | 99.6 | 99.6 |
26 μM BNPP | 3 | 1.2 ± 0.1 | 11.1 | 3.32-d |
Phosphate control | 3 | 0.9 ± 0.1 | 8.0 | −0.12-d
|
Boiled microsomes | 3 | 0.9 ± 0.0 | 8.0 | 0.02-d |
Control microsomes | 4 | 11.1 ± 0.4 | 100 | 100 |
25 μM Physostigmine2-a
| 4 | 2.9 ± 0.2 | 31.1 | 23.42-b |
25 μM Dexamethasone2-a
| 4 | 9.0 ± 0.8 | 96.9 | 96.6 |
Control with MeOH | 4 | 9.3 ± 0.8 | 83.3 | 81.8 |
25 μM cisplatin2-a
| 4 | 9.7 ± 1.8 | 105 | 106 |
25 μM prochlorper. Susp.2-a
| 4 | 8.7 ± 1.4 | 93.7 | 93.0 |
26 μM BNPP | 4 | 1.2 ± 0.0 | 10.9 | 2.82-c |
Phosphate control | 4 | 0.9 ± 0.0 | 8.4 | 0.12-c
|
Boiled microsomes | 4 | 0.9 ± 0.1 | 8.3 | 0.02-c
|