Kinetic parameters for the 7-hydroxylation of coumarin in a panel of 12 human liver microsomal preparations1-a
| Liver | Age | Sex | Ethnicity1-b | Drug History1-c | Pathology | Kmd | Vmax1-e |
|---|---|---|---|---|---|---|---|
| 109 | 46 | M | C | aa, I | Fatty liver | 0.62 | 5.28 |
| 119 | 24 | M | C | D | None | 0.49 | 3.35 |
| 127 | 38 | M | C | None | None | 0.44 | 1.09 |
| 129 | 36 | M | C | C, Pred, N | None | 0.31 | 8.01 |
| 131 | 62 | F | C | Praz, L, D, P | None | 0.39 | 13.99 |
| 134 | 7 | M | C | None | None | 0.43 | 4.69 |
| 135 | 45 | M | C | U | Fatty liver | 0.30 | 4.33 |
| 137 | 11 | M | AA | P | None | 0.31 | 4.04 |
| 138 | 9 | F | C | None | Acute liver injury | 0.16 | 0.64 |
| 139 | 15 | F | C | P | None | 0.55 | 22.58 |
| 146 | 10 | M | C | None | None | 0.51 | 7.11 |
| 149 | 63 | F | C | aa | Fibrotic | 0.34 | 0.97 |
| Mean ± SD | 0.40 ± 0.13 | 6.34 | |||||
| Variation | 4-fold | 36-fold |
↵1-a Values given are the average of duplicate determinations.
↵1-b AA, African-American; C, Caucasian.
↵1-c aa, alcohol abuse; I, inderal; D, dexamethasone; C, cyclosporine; Pred, prednisone; N, nifedipine; Praz, prazepam; P, phenytoin; L, lozol; U, urokinase.
1-d Expressed as μM.
↵1-e Expressed as nmol/nmol P450/min.