Table 3

Estimation of OLZ and its metabolites in a urine sample3-a

Compound% Urinary Radioactivity
10-N-glucuronide28.6
OLZ17.7
2-Carboxy OLZ5.2
N-Oxide OLZ3.9
N-Desmethyl OLZ0.8
 Total 56.2
  • 3-a Estimate is based on aqueous and ethyl acetate extracts of a urine sample from subject 1 (8–16 hr postdose).