Estimation of metabolite recovery in urine4-a
| Compound | % Dose |
|---|---|
| 10-N-Glucuronide4-b | 13.2 |
| N-Desmethyl-2-carboxy OLZ4-c | 3.8 |
| 2-Carboxy OLZ4-b | 3.5 |
| N-Oxide OLZ4-b | 3.4 |
| N-Oxide-2-carboxy OLZ | 2.3 |
| Glucuronide4-c , 4-d | |
| 4′-N-glucuronide4-c , 4-e | 2.1 |
| 2-Carboxy OLZ glucuronide4-c , 4-d | 2.1 |
| 2-Hydroxymethyl OLZ4-c | 1.4 |
| N-Desmethyl OLZ4-b | 0.6 |
| OLZ4-b | 7.3 |
| Total 39.7 |
↵4-a Based on total urinary recovery of ∼52%.
↵4-b Mean value determined from urine samples from two subjects (subject 1, 8–16 hr; subject 4, 4–8 hr).
↵4-c Based on urine samples from three subjects (subject 6, 16–72 hr; subject 1, 24–48 hr; subject 4, 24–72 hr).
↵4-d Tentative structural assignment.
↵4-e The amounts of 4′-N-glucuronide and 2-carboxy OLZ glucuronide were estimated after separation on an Inertsil C18 analytical column with a mobile phase of 1% acetic acid and acetonitrile.