Table 3

Correlations of human hepatic microsomal metabolites of BaP, NNK, NNAL, and NNN with cytochrome P450-dependent activities

	EROD	MP	BUF	CZ	NF	COUM
BaP
BaP-7,8-diol	0.63^*	0.043	−0.079	0.13	−0.20	−0.13
BaP-9,10-diol	0.65^*	0.042	−0.079	0.15	−0.31	−0.20
BaP-4,5-diol	0.60	0.55	0.13	0.49	0.53	0.21
3-OH-BaP	0.49	0.27	−0.055	0.378	0.46	0.16
1-OH-BaP	0.54	0.26	−0.091	0.21	0.33	0.078
9-OH-BaP	0.85^**	0.28	−0.25	0.40	−0.061	0.24
BaP quinones	0.73^*	0.079	−0.079	0.485	−0.24	0.091
NNK
Keto aldehyde	−0.030	0.26	−0.16	−0.091	0.86^**	0.38
Keto alcohol	0.19	0.25	0.092	0.20	0.39	−0.18
Diol	0.43	0.26	−0.30	−0.26	0.07	0.20
NNK-N-oxide	0.28	0.45	0.11	0.11	0.80^**	0.30
NNAL	0.05	−0.018	0.200	−0.37	−0.15	−0.48
NNAL
Lactol	0.079	0.37	−0.10	−0.030	0.89^**	0.43
Diol	0.27	0.56	0.067	0.21	0.82^**	0.21
Hydroxy acid	0.46	0.43	0.12	0.030	−0.078	0.018
NNAL-N-oxide	−0.14	0.43	0.13	0.012	0.73^*	−0.19
NNK	0.042	0.612	0.30	0.055	0.71^*	−0.10
NNN
Lactol	0.46	0.042	−0.43	0.26	0.33	0.72^*
Keto alcohol	−0.79	−0.58	−0.42	0.074	−0.22	−0.50

Spearman rank correlations were used. * p < 0.05; ** p < 0.01.