Inhibition of cerivastatin metabolism in human liver microsomes by coincubation with TAO
| Time | Incubation | Cerivastatin | M-1 | M-23 | M-24 | ||||
|---|---|---|---|---|---|---|---|---|---|
| % of radioactivity | |||||||||
| Start | Control4-a | 100 | — | — | — | ||||
| TAO14-b | 100 | — | — | — | |||||
| TAO24-c | 100 | — | — | — | |||||
| 0.5 hr | Control | 65.4 | 16.8 | 15.3 | 1.2 | ||||
| TAO1 | 74.7 | 12.2 | 12.1 | — | |||||
| TAO2 | 80.5 | 9.4 | 9.6 | — | |||||
| 1 hr | Control | 50.7 | 21.9 | 20.0 | 2.6 | ||||
| TAO1 | 60.1 | 17.4 | 18.1 | 1.2 | |||||
| TAO2 | 70.0 | 14.5 | 13.2 | 1.4 | |||||
| 2 hr | Control | 30.5 | 29.2 | 26.4 | 6.9 | ||||
| TAO1 | 44.6 | 23.3 | 25.3 | 3.4 | |||||
| TAO2 | 53.4 | 20.6 | 20.1 | 2.3 | |||||
| 3 hr | Control | 17.7 | 33.4 | 30.0 | 11.7 | ||||
| TAO1 | 29.7 | 28.1 | 30.3 | 5.7 | |||||
| TAO2 | 44.7 | 24.4 | 24.7 | 3.6 | |||||