Compound | Metabolite | Amount of Metabolite in Slice | ||
---|---|---|---|---|
nmol3-a | % of Drug-Related Radioactivity | % of Total Metabolite Formed3-a | ||
μM | ||||
Phenytoin (10) | Hydroxyphenytoin | 0.0758 ± 0.0289 | 5.3 | 46.6 ± 14.3 |
Phenytoin (50) | Hydroxyphenytoin | 0.1581 ± 0.0506 | 2.1 | 49.7 ± 16.7 |
Ondansetron (10) | 7-Hydroxydesmethylondansetron | 0.0098 ± 0.0090 | 0.6 | 17.5 ± 15.8 |
7-Hydroxyondansetron | 0.0866 ± 0.0401 | 5.7 | 14.8 ± 7.0 | |
Desmethylondansetron | 0.0376 ± 0.0168 | 2.5 | 33.9 ± 15.9 | |
Ondansetron (100) | 7-Hydroxyondansetron | 0.3080 ± 0.1083 | 2.2 | 15.1 ± 5.1 |
Desmethylondansetron | 0.3022 ± 0.1146 | 2.1 | 41.2 ± 17.4 | |
Diazepam (10) | 4′-Hydroxydiazepam | 0.2730 ± 0.1850 | 14.9 | 16.5 ± 5.3 |
3-Hydroxydiazepam | 0.0819 ± 0.0304 | 4.5 | 26.7 ± 8.7 | |
N-Desmethyldiazepam | 0.1862 ± 0.0615 | 10.1 | 38.7 ± 7.3 | |
Diazepam (100) | 4′-Hydroxydiazepam | 0.6496 ± 0.5410 | 4.0 | 22.3 ± 16.8 |
3-Hydroxydiazepam | 1.0454 ± 0.8205 | 6.4 | 24.9 ± 20.0 | |
N-Desmethyldiazepam | 1.4064 ± 0.9549 | 8.6 | 38.8 ± 31.4 |
↵3-a Mean data ± SD (N= 4).