Tissue | μg Eq Ritonavir/g | ||||||
---|---|---|---|---|---|---|---|
1 hr | 3 hr | 6 hr | 9 hr | 12 hr | 24 hr | 48 hr | |
Adrenals | 32.8 | 72.6 | 39.6 | 32.0 | 2.33 | 1.71 | 0.25 |
Brachial lymph nodes | 7.15 | 12.7 | 7.19 | 6.17 | 0.98 | 0.28 | ND |
Bladder | 4.85 | — | — | — | — | — | — |
Blood | 5.47 | 7.62 | 5.01 | 3.50 | 0.02 | 0.08 | ND |
Bone marrow | 10.0 | — | — | — | — | — | — |
Brain | 0.24 | 0.88 | 0.56 | 0.30 | 0.10 | 0.13 | 0.04 |
Eyes | 1.10 | 1.95 | 1.47 | 1.13 | ND | 0.34 | ND |
Fat | 9.05 | 12.6 | 7.93 | 5.54 | 0.38 | 0.41 | 0.06 |
Heart | 10.8 | 20.0 | 12.2 | 8.25 | 1.06 | 0.88 | 0.20 |
Kidneys | 23.1 | 37.0 | 22.8 | 17.5 | 2.03 | 2.22 | 0.76 |
Large intestine (with contents) | 14.6 | — | — | — | — | — | — |
Liver | 101 | 133 | 103 | 74.5 | 5.82 | 8.92 | 2.70 |
Lumbar lymph nodes | 5.42 | — | — | — | — | — | — |
Lungs | 13.1 | 21.0 | 15.3 | 12.5 | 2.15 | 1.66 | 0.49 |
Mediastinal lymph nodes | 6.42 | — | — | — | — | — | — |
Muscle | 6.16 | 10.9 | 6.88 | 4.04 | 0.52 | 0.39 | 0.14 |
Ovaries | 6.90 | 13.6 | 9.26 | 7.22 | 1.48 | 1.16 | 0.57 |
Pancreas | 14.9 | 41.1 | 19.3 | 17.2 | 2.66 | 2.65 | 0.31 |
Pituitary | 12.4 | — | — | — | — | — | — |
Plasma | 8.41 | 11.2 | 7.82 | 5.84 | 0.07 | 0.17 | ND |
Prostate | 3.32 | 7.86 | 8.64 | — | — | 1.53 | 0.50 |
Skin | 4.86 | — | — | — | — | — | — |
Small intestine (with contents) | 472 | — | — | — | — | — | — |
Spleen | 9.83 | 16.2 | 13.0 | 9.51 | 1.38 | 1.23 | 0.36 |
Stomach (with contents) | 1804 | — | — | — | — | — | — |
Submaxillary lymph nodes | 8.01 | 13.2 | 8.83 | 7.07 | 1.27 | 0.88 | 0.04 |
Testes | 0.40 | 1.22 | 1.52 | — | — | 0.54 | 0.46 |
Thymus | 6.25 | 11.6 | 7.90 | 6.16 | 1.34 | 1.34 | 0.46 |
Thyroid | 13.9 | 27.4 | 10.2 | 15.6 | ND | ND | ND |
Uterus | 4.60 | 7.07 | 5.70 | 4.65 | 1.19 | 1.18 | 0.60 |
ND = not detected; — = not determined; N = 3 female rats per time point, or 3 male rats per time point for testes and prostate.