Table 4

Mean tissue to plasma ratios in rats after oral administration of a 50 mg/kg dose of [14C]ritonavir

TissueTissue to Plasma Concentration Ratio
1 hr3 hr6 hr9 hr12 hr24 hr
Adrenals3.936.554.965.9435.112.8
Brachial lymph nodes0.881.130.901.1514.02.31
Bladder0.58
Blood0.650.680.640.600.260.31
Bone marrow1.20
Brain0.030.080.070.061.571.69
Eyes0.130.180.190.22ND3.36
Fat1.071.151.001.076.024.57
Heart1.271.781.521.5316.38.19
Kidneys2.753.342.953.5131.120.7
Large intestine (with contents)1.75
Liver12.112.413.515.486.776.7
Lumbar lymph nodes0.65
Lungs1.571.901.952.4433.218.4
Mediastinal lymph nodes0.78
Muscle0.731.000.860.768.193.91
Ovaries0.821.231.181.4622.911.2
Pancreas1.843.812.463.3342.331.1
Pituitary1.49
Prostate* 0.751.261.1918.2
Skin0.57
Small intestine (with contents)58.1
Spleen1.171.471.641.8620.310.3
Stomach (with contents)209
Submaxillary lymph nodes0.941.201.131.3619.18.69
Testes* 0.090.200.216.43
Thymus0.741.051.001.1820.38.85
Thyroid1.672.301.523.30NDND
Uterus0.550.640.730.8718.311.26
  • ND — not detected; — = not determined; N = 3 female rats per time point, or 3 male rats per time point for testes and prostate.

  • * Based on male rat plasma concentrations (not shown).