Table 5

Distribution of parent drug and metabolites in 0- to 6-hr bile of rats and dogs following a 5 mg/kg iv or a 20 mg/kg intraduodenal (id) dose of [14C]ritonavir

MetabolitePercent of Biliary Carbon-14
Male Rat IVFemale Rat IVMale Rat IDFemale Rat IDMale Dog IVMale Dog ID
Ritonavir1.912.70.510.01.50
M-1 8.011.83.318.24.43.6
M-2 12.622.06.515.27.96.0
M-3 1.42.61.42.04.54.0
M-5 8.15.014.47.410.14.6
M-6 00008.415.2
M-7/M-10 3.614.11.411.72.60
M-9 10.77.215.87.800
M-11 5-a 15.212.317.711.79.811.8
G-1 00009.618.1
G-2 00008.17.1
Total61.587.761.084.066.970.4
  • 5-a Percentages contain small, but unknown contributions from M-12 (rat and dog) and M-13(dog only). For each dosage route, N = 2 for rat,N = 1 for dog.