Urinary recovery (%) of metabolites of selegiline in humans (0–48 hr)
| Metabolites | Subject | Means ± SD | |||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | ||
| (R)-Amphetamine | 3.62 | 4.25 | 2.63 | 1.75 | 3.06 ± 0.95 |
| (R)-Methamphetamine | 44.08 | 43.68 | 27.96 | 32.10 | 36.96 ± 7.08 |
| Selegiline | 0.22 | 0.50 | 0.14 | 0.35 | 0.30 ± 0.14 |
| Desmethylselegiline | 0.97 | 0.95 | 0.19 | 0.24 | 0.59 ± 0.37 |
| (1R,2R)-Norpseudoephedrine | 0.03 | 0.05 | 0.01 | 0.03 | 0.03 ± 0.01 |
| (1S,2R)-Norephedrine | 0.09 | 0.19 | 0.07 | 0.13 | 0.12 ± 0.05 |
| (1R,2R)-Pseudoephedrine | 0.04 | 0.09 | 0.02 | 0.02 | 0.04 ± 0.03 |
| (1S,2R)-Ephedrine | 0.66 | 0.44 | 0.36 | 1.00 | 0.62 ± 0.25 |
| (R)-p-Hydroxyamphetamine | 2.71 | 1.90 | 3.32 | 3.90 | 2.96 ± 0.74 |
| (64.8) | (58.2) | (57.3) | (76.2) | (64.1 ± 7.6) | |
| (R)-p-Hydroxymethamphetamine | 5.96 | 2.94 | 9.10 | 13.64 | 7.91 ± 3.96 |
| (69.5) | (67.8) | (70.9) | (77.3) | (71.4 ± 3.6) | |
| Total recovery | 58.38 | 54.99 | 43.80 | 53.16 | 52.58 ± 5.41 |
Numbers in parentheses indicate percentage of the conjugated metabolites.