Binding and diffusion parameters of tacrolimus in whole blood reconstructed with plasma or buffer
| Parameters | Buffer | Joint | Plasma |
|---|---|---|---|
| Binding parameters | |||
| Hct fitted | 0.05, 0.1, 0.2, 0.4 | 0.1, 0.2, 0.4 | |
| KD (ng/ml) | 0.870 (6.4) | ||
| B max (ng/ml) | 440 (3.0) | ||
| γ | 1.33 (3.7) | ||
| Nsb | 4.22 (10.1) | ||
| fu | 0.537 (4.4) | ||
| Diffusion parameters | |||
| Hct fitted | 0.05, 0.1, 0.2, 0.4 | 0.1, 0.4 | |
| CL 12(ml/min) | 0.576 (1.1) | 0.276 (1.1) | |
| CL 21(ml/min) | 0.940 (1.6) | 1.70 (1.6) |
All data are presented as the parameter estimate (coefficient of variation, %). See Abbreviations for more information.