The effect of selective P450 inhibitors on theN-despropylation and hydroxylation of ropinirole in human liver microsomes
| Inhibitor | % Inhibition | |||
|---|---|---|---|---|
| N-Despropylation | Hydroxylation | |||
| H32 | H99 | H32 | H99 | |
| Furafylline (10 μM) | 80 | 74 | 75 | 49 |
| Sulphaphenazole (10 μM) | 0 | 0 | 0 | 0 |
| Quinidine (1 μM) | 8 | 0 | 9 | 4 |
| Ketoconazole (1 μM) | 15 | 43 | 9 | 50 |