Table 1

Steady-state concentration of quinolones in the serum, brain, brain ISF, and CSF of rats

AbbreviationUnitNFLXOFLXFLRXPFLX
Serum concentration Cp μg /ml8.97  ± 0.756.68  ± 1.405.46  ± 0.816.72  ± 0.15
Serum unbound fraction fu 0.795  ± 0.0170.768  ± 0.0540.683  ± 0.0290.727  ± 0.023
Serum unbound concentration Cp,u μg /ml7.14  ± 0.655.13  ± 0.963.76  ± 0.694.88  ± 0.21
Brain concentration C Brain μg /g0.232  ± 0.0841.02  ± 0.201.47  ± 0.221.52  ± 0.03
Brain dialysate concentration C dial μg /ml0.0040  ± 0.00100.0101  ± 0.00360.0093  ± 0.00100.0135  ± 0.0015
Brain ISF concentration C ISF μg /ml0.233  ± 0.0650.603  ± 0.2060.539  ± 0.0710.716  ± 0.034
CSF concentration C CSF μg /ml0.229  ± 0.0281.21  ± 0.301.55  ± 0.211.82  ± 0.26
Embedded Image Kp,u Brain ml /g0.035  ± 0.0140.200  ± 0.0210.394  ± 0.0120.312  ± 0.015
Embedded Image Kp,u CSF 0.033  ± 0.0060.234  ± 0.0210.420  ± 0.0240.369  ± 0.036
Formula 0.034  ± 0.0110.118  ± 0.0410.147  ± 0.0120.147  ± 0.004
Embedded Image 0.975  ± 0.3401.94  ± 0.372.72  ± 0.192.13  ± 0.14
Embedded Image 1.34  ± 0.480.567  ± 0.1330.371  ± 0.0270.473  ± 0.029
  • Each value represents the mean ± SE of three experiments.