Table 1

Steady-state concentration of quinolones in the serum, brain, brain ISF, and CSF of rats

	Abbreviation	Unit	NFLX	OFLX	FLRX	PFLX
Serum concentration	Cp	μg /ml	8.97 ± 0.75	6.68 ± 1.40	5.46 ± 0.81	6.72 ± 0.15
Serum unbound fraction	fu		0.795 ± 0.017	0.768 ± 0.054	0.683 ± 0.029	0.727 ± 0.023
Serum unbound concentration	Cp,u	μg /ml	7.14 ± 0.65	5.13 ± 0.96	3.76 ± 0.69	4.88 ± 0.21
Brain concentration	C _Brain	μg /g	0.232 ± 0.084	1.02 ± 0.20	1.47 ± 0.22	1.52 ± 0.03
Brain dialysate concentration	C _dial	μg /ml	0.0040 ± 0.0010	0.0101 ± 0.0036	0.0093 ± 0.0010	0.0135 ± 0.0015
Brain ISF concentration	C _ISF	μg /ml	0.233 ± 0.065	0.603 ± 0.206	0.539 ± 0.071	0.716 ± 0.034
CSF concentration	C _CSF	μg /ml	0.229 ± 0.028	1.21 ± 0.30	1.55 ± 0.21	1.82 ± 0.26
	Kp,u _Brain	ml /g	0.035 ± 0.014	0.200 ± 0.021	0.394 ± 0.012	0.312 ± 0.015
	Kp,u _CSF		0.033 ± 0.006	0.234 ± 0.021	0.420 ± 0.024	0.369 ± 0.036
$\text{[math]}$			0.034 ± 0.011	0.118 ± 0.041	0.147 ± 0.012	0.147 ± 0.004
			0.975 ± 0.340	1.94 ± 0.37	2.72 ± 0.19	2.13 ± 0.14
			1.34 ± 0.48	0.567 ± 0.133	0.371 ± 0.027	0.473 ± 0.029