Comparison of brain slice to medium concentration ratio among quinolones
| Quinolones | Slice-to-Medium Concentration Ratio (Cs/Cm) |
|---|---|
| ml/g | |
| NFLX | 1.91 ± 0.15 |
| OFLX | 1.37 ± 0.022-a |
| FLRX | 1.25 ± 0.152-a |
| PFLX | 1.33 ± 0.042-a |
| AM-1155 | 1.71 ± 0.04 |
| SPFX | 1.75 ± 0.04 |
Brain slice was incubated for 4 hr at 37°C in the incubation medium containing the respective quinolones at the concentration of 0.5 μg/ml.
Each value represents the mean ± SE of four experiments.
↵2-a Significantly different from NFLX, which was examined by multiple comparison testing, Tukey test (p < 0.01).