Inhibitor (Conc.) | Oxidation Rate (nmol/mg protein/min) of | ||||||
---|---|---|---|---|---|---|---|
6-Deoxypenciclovir | Famciclovir | ||||||
Human | Guinea Pig | Rabbit | AO-Active Rat | Guinea pig | Rabbit | AO-Active Rat | |
Control | 2.3 ± 1.0 | 20.4 ± 5.6 | 30.0 ± 4.8 | 4.3 ± 1.7 | 59.3 ± 14.7 | 47.3 ± 5.4 | 15.0 ± 3.5 |
Menadione (1 μM) | 0.8 ± 0.23-c | 3.6 ± 2.13-c | 5.5 ± 3.13-b | 2.5 ± 0.53-b | 9.7 ± 8.33-c | 5.1 ± 2.73-b | 3.3 ± 1.23-c |
Isovanillin (10 μM) | 0.6 ± 0.13-d | 4.0 ± 2.23-d | ND | 1.2 ± 0.63-c | 10.0 ± 7.93-d | ND | 3.0 ± 1.53-b |
Allopurinol (100 μM) | 2.1 ± 0.1 | 19.0 ± 5.1 | 24.3 ± 3.0 | 3.6 ± 0.93-f | 52.3 ± 14.6 | 40.7 ± 11.5 | 14.0 ± 3.5 |
↵3-a Mean ± SD (N = 3).
Results are significantly different from control incubation at
↵3-b p < 0.005,
↵3-c p <0.02 and
↵3-d p < 0.05 (pairedt-test).
Not determined.
↵3-f Oxidation rate of 6-deoxypenciclovir with AO-active rat liver enzyme in the presence of 100 μM menadione and 100 μM allopurinol = 0 nmol/mg protein/min.